About 30 million people diagnosed with type 2 diabetes and their condition can’t yet be cured for lifelong in the United States.
The major risk factor is obesity which is rising among the number of people with type 2 diabetes.
The disease is occurred by faulty beta cells in the pancreas which manufacture, store and release insulin, the hormone that is essential for controlling glucose levels in the blood.
If beta cells become dysfunctional then the body can not make insulin to control blood sugar and the levels of glucose can rise to the dangerous level.
The researchers from Salk Institute in the US using a well-known compound such as vitamin D which is proved in cells and mouse beneficial in treating these damaged cells.
Ronald Evans, from Salk Institute for Biological Studies in California, US, said, “We know that diabetes is a disease caused by inflammation. We identified the Vitamin D receptor as an important modulator of both inflammation and beta cell survival.”
The researchers used beta cells which are created from embryonic stem cells and they were able to found a compound, iBRD9, that appeared to improve the activation of the vitamin D receptor when it was combined with vitamin D to improve the survival of beta cells.
The team conducting a screening test to found the compounds which can improve the survival of beta cells in a dish. They tested it in a mouse model of diabetes and found that it could bring glucose back to normal levels in the animals.
Wei, a first author of the study published in the journal Cell, said, “Epidemiological studies in patients have suggested a correlation between high vitamin D concentrations in the blood and a lower risk of diabetes, but the underlying mechanism was not well understood.”
He said, “It been hard to protect beta cells with the vitamin alone. We now have some ideas about how we might be able to take advantage of this connection.”